Prioritizing Treatment Options in Breast Cancer

Tuesday, Jul 3 2018

When a patient with metastatic breast cancer fails to respond to conventional treatment and gene analysis identifies several targetable molecular mutations, how do you prioritize treatment options?

Hadassah Medical Center oncologists, together with Weizmann Institute of Science and Hebrew University colleagues, dealt with this dilemma of prioritizing treatment through an ex-vivo organ culture (EVOC) system. Having found several mutations of the tumor, doctors treated the tumor outside the body (EVOC) with several agents recommended for that particular mutation profile. The tumor response to those agents was then analyzed. Later, the patient herself received the treatment that showed the best tumor shrinkage in the EVOC.

The authors, whose article on the subject appears in the April 13, 2018, issue of Cancer Biology and Therapy, note that their findings “provide a potential rationale for utilizing the EVOC system to predict tumor response to targeted therapy when multiple targets are proposed.”

Related Stories


Tuesday, Jan 12 2021

Hadassah Speedily Vaccinates Its Staff Against COVID-19

As of January 11, out of the 6,500 individuals who work at the Hadassah Medical Organization, 4,800 had received their first dose of the Pfizer vaccine, and 1,000 had received the second dose.


Tuesday, Jan 5 2021

Mary, From Bethlehem, Experiences Personal Christmas Miracle at Hadassah

Christmas Eve is always a special time for Mary A, an 86-year-old resident of Bethlehem.


Tuesday, Dec 29 2020

Nurses Inject Hope at Hadassah Hospital Ein Kerem

The sun has just come up. It is 6 am and 18 pairs of eyes are staring at two Hadassah Hospital Ein Kerem nurses. One nurse is seated and the other is standing over her, a needle in hand.


Monday, Dec 21 2020

What Are Organoids? Welcome to a Revolution in Basic Medical Science

Classically, researchers in basic medical science have had two tools: in vitro cultures and animal models. The challenges posed by their limitations are many.


Donation Questions

(800) 928-0685

Membership Questions

(800) 664-5646

Israel Travel

(800) 237-1517

Contact Us

40 Wall Street

New York, NY 10005

More ›

Show More